Refer to BC Drug and Poison Information Centre (DPIC) Poison Management Manual.Ĭan be very complex – consult BC DPIC early.Varies with agent, presence of co-ingestants and underlying cardiac disease. ![]() Potassium channel blocking effects of sotalol can result in QTc interval prolongation.Alpha adrenergic blocking activity of carvedilol and labetalol may result in pronounced hypotension through peripheral vasodilation.Membrane stabilizing effects (sodium channel blockade) of propranolol and acebutolol, can result in QRS prolongation, reduced contractility, and ventricular dysrhythmias.Non-selective beta blockers also antagonize beta-2 receptors, causing bronchoconstriction, however, this is rare. ![]() Beta-1 adrenergic antagonism reduces heart rate, conduction velocity and contractility.QRS prolongation by agents with membrane stabilizing effects (acebutolol, propranolol).QT prolongation with some agents (sotolol).Less common: CNS effects including coma and seizures may be seen.calcium channel blockers, digoxin) or who have underlying cardiac disease. ![]()
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